Article

Integration of Tumour Sequencing and Case-Control Data to Assess Pathogenicity of RAD51C Missense Variants in Familial Breast Cancer

2021-03-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> While protein truncating variants in <italic>RAD51C</italic> have been shown to predispose to triple negative breast cancer (TNBC) and ovarian cancer, little is known about the pathogenicity of missense (MS) variants. <bold>Methods: </bold>The frequency of rare <italic>RAD51C</italic> MS variants were assessed in the BEACCON study of 5,734 familial breast cancer...

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Literature Corpus work: 87de6ed1-d600-5048-a3fc-796c43a0e9d1
DOI: 10.21203/rs.3.rs-294874/v1

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