Article

Machine learning predicts translation initiation sites in neurologic diseases with expanded repeats

2021-08-17

Abstract excerpt

A number of neurologic diseases, including a form of amyotrophic lateral sclerosis and others associated with expanded nucleotide repeats have an unconventional form of translation called repeat-associated non-AUG (RAN) translation. Repeat protein products accumulate and are hypothesized to contribute to disease pathogenesis. It has been speculated that the repeat regions in the RNA fold into secondary structures...

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Literature Corpus work: 87ada7be-e977-5331-84cc-cec8ffc36303
DOI: 10.1101/2021.08.17.456657

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