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Article

Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions

1 Jun 2022

Abstract excerpt

A number of neurologic diseases associated with expanded nucleotide repeats, including an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation called repeat-associated non-AUG (RAN) translation. It has been speculated that the repeat regions in the RNA fold into secondary structures in a length-dependent manner, promoting RAN translation. Repeat protein products are...

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PMID: 35648796
DOI: 10.1371/journal.pone.0256411

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