Leveraging hierarchical structures for genetic block interaction studies using the hierarchical transformer

Abstract excerpt

Initially introduced in 1909 by William Bateson, classic epistasis (genetic variant interaction) refers to the phenomenon that one variant prevents another variant from a different locus from manifesting its effects. The potential effects of genetic variant interactions on complex diseases have been recognized for the past decades. Moreover, It has been studied and demonstrated that leveraging the combined SNP eff...

Topics

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• Algorithms
• Computational Biology
• Deep Learning
• Epistasis, Genetic
• Genome-Wide Association Study
• Machine Learning
• Neural Networks, Computer
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

87aa46fd-5339-5e74-a282-2c4cbffa1611

DOI

10.1101/2024.11.18.24317486