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EpiHNet: Detecting epistasis by heterogeneous molecule network.

Methods (San Diego, Calif.) - 1 Feb 2022

Wang Xin, Zhang Huiling, Wang Jun, Yu Guoxian, Cui Lizhen, Guo Maozu

Abstract excerpt

Epistasis between single nucleotide polymorphisms (SNPs) plays an important role in elucidating the missing heritability of complex diseases. Diverse approaches have been invented for detecting SNP interactions, but they canonically neglect the important and useful connections between SNPs and other bio-molecules (i.e., miRNAs and lncRNAs). To comprehensively model these disease related molecules, a heterogeneous...

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PMID: 34555529
DOI: 10.1016/j.ymeth.2021.09.007

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