Article

CTCF loss induces giant lamellar bodies in Purkinje cell dendrites

2022-09-07

Abstract excerpt

<title>Abstract</title> <p>Loss of Purkinje cells (PCs) in the cerebellum causes severe motor deficits. The peculiar lamellar structures known as “giant lamellar bodies” (GLBs) have been reported in PCs of patients with Werdnig-Hoffman disease, 13q deletion syndrome, and Krabbe’s disease. GLBs are localized to PC dendrites and are associated with neurodegeneration. They have been noted, however, only in case repo...

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Literature Corpus work: 87a94da5-e99b-5c98-b11d-4e067262aa3c
DOI: 10.21203/rs.3.rs-1970261/v1

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