Article

siRNA Mediated Genetic Perturbation of Primary Human Leukemia Stem and Progenitor Cells

2025-09-20

Abstract excerpt

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are aggressive hematologic malignancies with poor outcomes. Leukemia stem and progenitor cells (LSPCs) are a subset of cells within the bulk tumor thought to be responsible for initiating disease and causing relapse. LSPCs evade chemotherapy partially due to their quiescent state. Therefore, studying this cell subpopulation is critical to identify ne...

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Literature Corpus work: 879818f7-3783-51c8-9d6d-7c87d2cadb50
DOI: 10.1101/2025.09.17.676969

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