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Article

Induced Apoptosis Investigation in Wild-type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single-cell qRT-PCR.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2016

Gao Keliang, Huang Xiaomeng, Chiang Chi-Ling, Wang Xinmei, Chang Lingqian, Boukany Pouyan, Marcucci Guido, Lee Robert, Lee Ly James

Abstract excerpt

Nanochannel electroporation (NEP) was applied to deliver precise dosages of myeloid cell leukemia-1 (Mcl-1)-specific siRNA and molecular beacons to two types of acute myeloid leukemia (AML) cells, FMS-like tyrosine kinase-3 wild-type (WT) and internal tandem duplications (ITD) type at the single-cell level. NEP, together with single-cell quantitative reverse transcription PCR, led to an observation showing nearly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Myeloid Cell Leukemia Sequence 1 Protein

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Source

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Identifiers

PMID: 26782640
DOI: 10.1038/mt.2016.6
PMCID: PMC4881776

Genes

MCL1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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