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Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

4 Mar 2021

Abstract excerpt

Abstract Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4 + T cells (T EM cells). Pre-therapy CD4 + T EM cell expansion occurs primarily during autumn or winter in patients with...

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PMID: 33664251
DOI: 10.1038/s41467-021-21572-y

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