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Article

Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes.

eLife - 19 Aug 2024

Bitar Sara, Baumann Timo, Weber Christopher, Abusaada Majd, Rojas-Charry Liliana, Ziegler Patrick, Schettgen Thomas, Randerath Isabella Eva, Venkataramani Vivek, Michalke Bernhard, Hanschmann Eva-Maria, Arena Giuseppe, Krueger Rejko, Zhang Li, Methner Axel

Abstract excerpt

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. Familial cases of PD are often caused by mutations of PTEN-induced kinase 1 (PINK1) and the ubiquitin ligase Parkin, both pivotal in maintaining mitochondrial quality control. CISD1, a homodimeric mitochondrial iron-sulfur-binding protein, is a major target of Parkin-mediated...

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Identifiers

PMID: 39159312
DOI: 10.7554/eLife.97027
PMCID: PMC11383524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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