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Z-DNA-binding protein 1-mediated programmed cell death: Mechanisms and therapeutic implications

25 Aug 2025

Abstract excerpt

ABSTRACT: Programmed cell death (PCD) is characterized as a cell death pathway governed by specific gene-encoding requirements, plays crucial roles in the homeostasis and innate immunity of organisms, and serves as both a pathogenic mechanism and a therapeutic target for a variety of human diseases. Z-DNA-binding protein 1 (ZBP1) functions as a cytosolic nucleic acid sensor, utilizing its unique Zα domains to...

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PMID: 40851365
DOI: 10.1097/cm9.0000000000003737

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