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Article

Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells

15 Dec 2020

Abstract excerpt

ONC201 is the first member of the imipridone family of anticancer drugs to enter the clinic for the treatment of diverse solid and hematologic cancers. A subset of pediatric and adult patients with highly aggressive brain tumors has shown remarkable clinical responses to ONC201, and recently, the more potent derivative ONC206 entered clinical trials as a single agent for the treatment of central nervous system...

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PMID: 33336683
DOI: 10.1093/neuonc/noaa283

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