Article

Mechanobiological Conditioning of Mesenchymal Stem Cells Enhances Therapeutic Angiogenesis by Inducing a Hybrid Pericyte-Endothelial Phenotype

2018-12-05

Abstract excerpt

Stem cell therapies have great promise for revolutionizing treatments for cardiovascular disease and other disorders but have not yet achieved their potential due to poor efficacy and heterogeneity in patient response. Here, we used a novel high throughput screening system to optimize the conditioning of mesenchymal stem cells using a combinatorial set of biochemical factors, pharmacological inhibitors and biomech...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87101ca5-2406-5f52-a03d-e4d45105d74b
DOI: 10.1101/487710

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanobiological Conditioning of Mesenchymal Stem Cells Enhances Therapeutic Angiogenesis by Inducing a Hybrid Pericyte-Endothelial PhenotypeDOI 10.1101/487710Read

Concise Review: Mechanotransduction via p190RhoGAP Regulates a Switch Between Cardiomyogenic and Endothelial Lineages in Adult Cardiac ProgenitorsSemantic proximity Read

Mechanobiology: A landscape for reinterpreting stem cell heterogeneity and regenerative potential in diseased tissuesSemantic proximity Read

Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhances Angiogenesis In Vivo at a Low-Cell DoseSemantic proximity Read

High Throughput Mechanobiological Screens Enable Mechanical Priming of Pluripotency in Mouse FibroblastsSemantic proximity Read

Physiologically-Modeled Dynamic Stimulation and Growth Factors Induce Differentiation of Mesenchymal Stem Cells to a Vascular Endothelial Cell Phenotype.Semantic proximity Read

4D force patterning enables spatial control of angiogenesisSemantic proximity Read

Human Pluripotent Stem Cell Mechanobiology: Manipulating the Biophysical Microenvironment for Regenerative Medicine and Tissue Engineering ApplicationsSemantic proximity Read

Constructing stem cell microenvironments using bioengineering approachesSemantic proximity Read

Fluid shear stress promotes an endothelial-like phenotype during the early differentiation of embryonic stem cells.Semantic proximity Read

Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation.Semantic proximity Read

Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor ArraysSemantic proximity Read

Mechanical regulation of cellular phenotype: implications for vascular tissue regeneration.Semantic proximity Read