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Constructing stem cell microenvironments using bioengineering approaches

25 Sept 2013

Abstract excerpt

Within the adult organism, stem cells reside in defined anatomical microenvironments called niches. These architecturally diverse microenvironments serve to balance stem cell self-renewal and differentiation. Proper regulation of this balance is instrumental to tissue repair and homeostasis, and any imbalance can potentially lead to diseases such as cancer. Within each of these microenvironments, a myriad of...

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PMID: 24064536
DOI: 10.1152/physiolgenomics.00099.2013

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