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Article

Physiologically-Modeled Dynamic Stimulation and Growth Factors Induce Differentiation of Mesenchymal Stem Cells to a Vascular Endothelial Cell Phenotype.

Microcirculation (New York, N.Y. : 1994) - 1 Apr 2025

Gurel Mediha, Zomer Helena, McFetridge Calum, Murfee Walter L, McFetridge Peter S

Abstract excerpt

OBJECTIVE: Mesenchymal stem cells (MSCs) represent an attractive option as an endothelial cell (EC) source for regenerative medicine therapies. However, the differentiation of MSCs toward an ECs phenotype can be regulated by a complex and dynamic microenvironment, including specific growth factors as well as local mechanical cues. The objective of this work was to evaluate whether Physiologically-modeled dynamic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40120632
DOI: 10.1111/micc.70007
PMCID: PMC12012511

Genes

MSC
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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