Article

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

2020-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Alterations to androgen receptor (AR) signalling and cellular metabolism are hallmarks of prostate cancer. This study uncovers a novel link between AR and the pentose phosphate pathway (PPP) through 6-phosphogluoconate dehydrogenase ( 6PGD ), an androgen-regulated gene that is upregulated in prostate cancer. Knockdown of 6PGD impairs growth and elicits death of prostate cancer cells, at least i...

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Literature Corpus work: 8700eae0-758e-50c3-98e4-26402070e807
DOI: 10.1101/2020.09.02.279356

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