Article

<i>STAT3</i> -dependent systems-level analysis reveals <i>PDK4</i> as an independent predictor of biochemical recurrence in prostate cancer

2019-09-19

Abstract excerpt

Prostate cancer (PCa) has a broad spectrum of clinical behaviour, hence biomarkers are urgently needed for risk stratification. We previously described the protective effect of STAT3 in a prostate cancer mouse model. By utilizing a gene co-expression network in addition to laser microdissected proteomics from human and murine prostate FFPE samples, we describe STAT3-induced downregulation of the TCA cycle/OXPHOS i...

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Literature Corpus work: a75e0b56-5b97-575f-9f75-d28a8f9b7c42
DOI: 10.1101/770701

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