Article

Nicotinamide Riboside alleviates exercise intolerance in ANT1-deficient mice

2022-02-26

Abstract excerpt

<h4>Summary</h4> Mitochondrial disorders are often characterized by muscle weakness and fatigue. Null mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) of both humans and mice cause cardiomyopathy and myopathy associated with exercise intolerance and muscle weakness. We have analyzed the exercise physiology of mice deficient in ANT1, demonstrating a peripheral limitation of skeletal m...

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Literature Corpus work: 86df8f79-35e4-5b2f-84c2-1258fc93362e
DOI: 10.1101/2022.02.25.481689

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