Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation and gut microbiota composition in a twin study

Abstract excerpt

<h4>Summary</h4> NAD + precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice. However, most short-term clinical trials conducted so far have failed to report positive outcomes. Therefore, we aimed to determine whether long-term NR supplementation boosts mitochondrial biogenesis and metabolic health in humans....

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Genomics, phytochemicals, and oxidative stress
• Gut microbiota and health
• Mitochondrial Function and Pathology
• PARP inhibition in cancer therapy
• Sirtuins and Resveratrol in Medicine
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

e879e454-92b7-5a91-9ea2-82d4e891ddc7

DOI

10.1101/2022.04.27.22274380