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Article

Exercise triggers ARVC phenotype in mice expressing a disease-causing mutated version of human plakophilin-2.

Journal of the American College of Cardiology - 14 Apr 2015

Cruz Francisco M, Sanz-Rosa David, Roche-Molina Marta, García-Prieto Jaime, García-Ruiz José M, Pizarro Gonzalo, Jiménez-Borreguero Luis J, Torres Miguel, Bernad Antonio, Ruíz-Cabello Jesús, Fuster Valentín, Ibáñez Borja, Bernal Juan A

Abstract excerpt

BACKGROUND: Exercise has been proposed as a trigger for arrhythmogenic right ventricular cardiomyopathy (ARVC) phenotype manifestation; however, research is hampered by the limited availability of animal models in which disease-associated mutations can be tested. OBJECTIVES: This study evaluated the impact of exercise on ARVC cardiac manifestations in mice after adeno-associated virus (AAV)-mediated gene delivery...

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Share to Arrhythmogenic Right Ventricular Dysplasia
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

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Share to Physical Conditioning, Animal

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Source

Identifiers

PMID: 25857910
DOI: 10.1016/j.jacc.2015.01.045

Genes

PKP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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