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Article

Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.

The Journal of clinical investigation - 1 Jul 2006

Garcia-Gras Eduardo, Lombardi Raffaella, Giocondo Michael J, Willerson James T, Schneider Michael D, Khoury Dirar S, Marian Ali J

Abstract excerpt

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is a genetic disease caused by mutations in desmosomal proteins. The phenotypic hallmark of ARVC is fibroadipocytic replacement of cardiac myocytes, which is a unique phenotype with a yet-to-be-defined molecular mechanism. We established atrial myocyte cell lines expressing siRNA against desmoplakin (DP), responsible for human ARVC. We show...

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Identifiers

PMID: 16823493
DOI: 10.1172/JCI27751
PMCID: PMC1483165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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