Article

A novel dephosphorylation peptide inhibits 17β-HSD1 enzyme activity in ovarian granulosa cells and breast cancer cells

2025-12-29

Abstract excerpt

Estradiol (E 2 ), a pivotal mammalian reproductive hormone, is closely associated with estrogen-dependent diseases. 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), a critical E 2 synthesis enzyme, has been understudied for its post-translational regulation-despite its potential as a therapeutic target, no clinically approved inhibitors are currently available. In our investigation of porcine follicular atres...

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Literature Corpus work: 86ae10c0-bffa-58ee-b8f0-7a6a289ceb36
DOI: 10.64898/2025.12.29.696806

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