Article
Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice.
International journal of molecular sciences - 27 Apr 2022
Heinosalo Taija, Rytkönen Kalle T, Saarinen Niina, Järvensivu Päivi, Damdimopoulou Pauliina, Strauss Leena, Orasniemi Satu, Horshauge Petricia, Gabriel Michael, Koskimies Pasi, Ohlsson Claes, Kronqvist Pauliina, Poutanen Matti
Abstract excerpt
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice universally over-expressing human estrogen biosynthetic enzyme HSD17B1 (HSD17B1TG mice) present with adenomyosis phenotype, characterized by histological and molecular evaluation....
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