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Article

Variations in DNA Repair Genes and Intratumoral Genetic Heterogeneity in Temozolomide-Resistant Glioblastoma.

Human mutation - 1 Jan 2026

Chen Weixuan, Li Cong, Liu Yun, Huang Hengji

Abstract excerpt

Background: Glioblastoma (GBM) is the most prevalent primary brain tumor. Despite extensive investigations, GBM's resistance to the first-line drug temozolomide (TMZ) remains a major challenge in clinical management. This study explores the molecular mechanisms underlying TMZ resistance in GBM, emphasizing the roles of DNA repair gene polymorphisms and intratumoral genetic heterogeneity. Methods: In this study,...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41969610
DOI: 10.1155/humu/3430617
PMCID: PMC13067060

Genes

MGMT
OGG1
PNKP
XAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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