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Article

Position-dependent function of human sequence-specific transcription factors.

Nature - 1 Jul 2024

Duttke Sascha H, Guzman Carlos, Chang Max, Delos Santos Nathaniel P, McDonald Bayley R, Xie Jialei, Carlin Aaron F, Heinz Sven, Benner Christopher

Abstract excerpt

Patterns of transcriptional activity are encoded in our genome through regulatory elements such as promoters or enhancers that, paradoxically, contain similar assortments of sequence-specific transcription factor (TF) binding sites1-3. Knowledge of how these sequence motifs encode multiple, often overlapping, gene expression programs is central to understanding gene regulation and how mutations in non-coding DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39020164
DOI: 10.1038/s41586-024-07662-z
PMCID: PMC11269187

Genes

TF
NRF1

Provenance

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