Article

Retrotransposons facilitates tissue specific horizontal transfer of circulating tumor DNA between human cells

2022-08-11

Abstract excerpt

A variety of organisms have been shown to have altered physiology or developed pathology due to gene transfer, but mammals have never been shown to do so. Here, we show that circulating tumor DNA (ct) can promote cell-specific horizontal gene transfer (HGT) between human cancer cells and explain the mechanisms behind this phenomenon. Once ctDNA enters the host cell, it migrates to the nucleus and integrates into t...

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Identifiers and source

Literature Corpus work: 865db2fb-36c1-5701-8b80-e321cdf9a5c3
DOI: 10.1101/2022.08.10.501131

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