Article
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences.
Nature communications - 1 Feb 2011
Balaj Leonora, Lessard Ryan, Dai Lixin, Cho Yoon-Jae, Pomeroy Scott L, Breakefield Xandra O, Skog Johan
Abstract excerpt
Tumour cells release an abundance of microvesicles containing a selected set of proteins and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the genetic status of the tumour, including amplification of the oncogene c-Myc. We also find amplified c-Myc in serum microvesicles from tumour-bearing mice. Further, we find remarkably high levels of retrotransposon RNA transcripts, especially...
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