Article

Gene and protein sequence features augment HLA class I ligand predictions

2023-09-05

Abstract excerpt

The sensitivity of malignant tissues to T cell-based cancer immunotherapies is dependent on the presence of targetable HLA class I ligands on the tumor cell surface. Peptide intrinsic factors, such as HLA class I affinity, likelihood of proteasomal processing, and transport into the ER lumen have all been established as determinants of HLA ligand presentation. However, the role of sequence features at the gene and...

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Literature Corpus work: 863de7a3-e257-59d7-a3a5-14b9faf93096
DOI: 10.1101/2023.09.03.556079

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