Article

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

2021-08-26

Abstract excerpt

Duchenne muscular dystrophy (DMD) affects myofibers and muscle stem cells (SC), causing progressive muscle degeneration and repair defects. It was not known whether dystrophic myoblasts—the effector cells of muscle growth and regeneration—are affected. Using a combination of transcriptomic, molecular, functional analyses, and genome-scale metabolic modelling, we demonstrate, for the first time, convergent cell-aut...

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Literature Corpus work: 6ed4ea51-eac5-589d-a896-84e81760f26d
DOI: 10.1101/2021.08.24.457331

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