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Article

Substance P enhanced titanium particles-induced RANKL expression in fibroblasts from periprosthetic membrane.

Connective tissue research - 1 Jan 2013

Qian Yebin, Zhang Xian-long, Zeng Bing-Fang, Jiang Yao, Shen Hao, Wang Qi

Abstract excerpt

Aseptic loosening remains the primary cause of failure in total joint arthroplasty. Implant-derived particles are thought to be a main cause of osteolysis that leads to the failure. Substance P (SP) immunoreactive nerve fibers have been detected in the periprosthetic membrane of aseptic loose hip prostheses. We isolated fibroblasts from periprosthetic membrane. Fibroblasts were examined by real-time RT-PCR and...

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Identifiers

PMID: 23869610
DOI: 10.3109/03008207.2013.823953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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