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Article

Synovial-tissue resident macrophages play proinflammatory functions in the pathogenesis of RA while maintaining the phenotypes in the steady state.

Immunological medicine - 1 Jun 2024

Kai Kazuhiro, Yamada Hisakata, Tsurui Ryosuke, Sakuraba Koji, Fujimura Kenjiro, Kawahara Shinya, Akasaki Yukio, Tsushima Hidetoshi, Fujiwara Toshifumi, Hara Daisuke, Fukushi Jun-Ichi, Sawa Shinichiro, Nakashima Yasuharu

Abstract excerpt

Synovial tissue-resident macrophages (STRMs) maintain normal joint homeostasis in a steady state. However, it is unclear whether STRMs still play homeostatic roles or change the functions in the joint of rheumatoid arthritis (RA), where infiltrating peripheral blood monocyte-derived macrophages (PBMoMs) play proinflammatory roles. In the present study, we examined changes in the phenotypes and functions of STRMs...

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Identifiers

PMID: 38168669
DOI: 10.1080/25785826.2023.2300853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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