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The state of CD44 activation in cancer progression and therapeutic targeting

3 Sept 2021

Abstract excerpt

CD44, a non-kinase transmembrane glycoprotein, is ubiquitously expressed on various types of cells, especially cancer stem cells (CSCs), and has been implicated in cancer onset and aggressiveness. The major ligand for the CD44, hyaluronan (HA), binds to and interacts with CD44, which in turn triggers downstream signaling cascades, thereby promoting cellular behaviors such as proliferation, motility, invasiveness...

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PMID: 34478583
DOI: 10.1111/febs.16179

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