Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD44: A Multifunctional Mediator of Cancer Progression

9 Dec 2021

Abstract excerpt

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition (EMT) capability, as well as a resistance to chemo- and radiotherapy. The CD44 gene regularly undergoes alternative splicing, resulting in the standard (CD44s)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Oral and Maxillofacial Pathology
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34944493
DOI: 10.3390/biom11121850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD44: A Multifunctional Mediator of Cancer ProgressionPMID 34944493Read ↗

CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer CellsSemantic proximity Read ↗

CD44 and its implication in neoplastic diseasesSemantic proximity Read ↗

CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic nichesSemantic proximity Read ↗

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic TargetSemantic proximity Read ↗

The normal structure and function of CD44 and its role in neoplasiaSemantic proximity Read ↗

The Cancer Stem Cell Marker CD44 Play Key Roles in Immune Suppression/Evasion, Drug Resistance, Epithelial-Mesenchymal Transition, and Metastasis in Several Human CancersSemantic proximity Read ↗

Cancer Stem Cell Marker CD44 Plays Multiple Key Roles in Human Cancers: Immune Suppression/Evasion, Drug Resistance, Epithelial–Mesenchymal Transition, and MetastasisSemantic proximity Read ↗

CD44 as a potential diagnostic tumor markerSemantic proximity Read ↗

The CD44 protein family.Semantic proximity Read ↗

Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression.Semantic proximity Read ↗

The state of CD44 activation in cancer progression and therapeutic targetingSemantic proximity Read ↗

Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.