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RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer

26 Sept 2020

Abstract excerpt

Autophagy is a highly conserved lysosome-dependent degradation system in eukaryotic cells. This process removes long-lived intracellular proteins, damaged organelles, and recycles biological material to maintain cellular homeostasis. Dysfunction of autophagy triggers a wide spectrum of human diseases, including cancer and neurodegenerative diseases. In the present study, we show that RNF115, an E3 ubiquitin...

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PMID: 32980859
DOI: 10.1038/s41419-020-03011-w

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