Article

High-Intensity Interval Training Modulates APP Expression and Reduces Neuronal Apoptosis in a β-Amyloid-Induced Model of Alzheimer’s Disease: Hippocampal Evidence

2026-05-21

Abstract excerpt

<title>Abstract</title> <p>High-intensity interval training (HIIT) has emerged as a promising non-pharmacological strategy for neuroprotection, although its molecular effects in Alzheimer’s disease (AD) remain unclear. This study investigated the effects of HIIT on gene expression (FNDC5, PPARGC1A, APP), protein expression, cognitive performance, and neuronal apoptosis in a β-amyloid-induced rat model of AD. Sixt...

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Literature Corpus work: 85d26db6-b8a7-5413-a5d7-05b61de374f6
DOI: 10.21203/rs.3.rs-9728151/v1

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