Article

Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau and improve cognitive ability in APP/PS1 Transgenic Mice

2022-06-22

Abstract excerpt

<h4>Background: </h4> Moderate physical exercise has beneficial effects on the brains of healthy humans and AD patients. Previous reports have suggested that treadmill exercise plays an anti-AD role and improves cognitive ability by promoting amyloid clearance, inhibiting neuronal apoptosis, reducing oxidative stress level, alleviating brain inflammation, and promoting autophagy- lysosome pathway in AD mice. Howev...

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Literature Corpus work: dbefe658-9fed-5744-b1d1-982247464d45
DOI: 10.21203/rs.3.rs-1758813/v1

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