Article

Mouse Fc-FcγRIV structure guides Fc engineering for cross-species FcγR recognition

2026-05-15

Abstract excerpt

Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action for many FDA-approved therapeutic antibodies that is driven by interactions between the antibody Fc and Fcγ receptors (FcγRs) on immune effector cells. Murine models used for preclinical antibody evaluation currently have limited predictive value for clinical ADCC performance due to interspecies differences in Fc-FcγR interactions. The...

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Literature Corpus work: 85c9d33d-8bf2-54cc-9b9c-af435c1c441b
DOI: 10.64898/2026.05.12.724433

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