Article

Expression of progerin does not result in an increased mutation rate

2016-04-06

Abstract excerpt

In the premature ageing disease Hutchinson-Gilford progeria syndrome (HGPS) the underlying genetic defect in the lamin A gene leads to accumulation at the nuclear lamina of progerin – a mutant form of lamin A that cannot be correctly processed. This has been reported to result in defects in the DNA damage response and in DNA repair, leading to the hypothesis that, as in normal ageing and in other progeroid syndro...

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Literature Corpus work: 85bceef4-84c6-538c-ac8e-0f2df6552e85
DOI: 10.1101/047506

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