Article
Expression of progerin does not result in an increased mutation rate.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Oct 2017
Deniaud Emmanuelle, Lemaître Charlene, Boyle Shelagh, Bickmore Wendy A
Abstract excerpt
In the premature ageing disease Hutchinson-Gilford progeria syndrome (HGPS), the underlying genetic defect in the lamin A gene leads to accumulation at the nuclear lamina of progerin-a mutant form of lamin A that cannot be correctly processed. This has been reported to result in defects in the DNA damage response and in DNA repair, leading to the hypothesis that, as in normal ageing and in other progeroid...
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