Article

Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal new properties of the cardiac voltage-gated sodium channel

2023-07-10

Abstract excerpt

Voltage-gated sodium (Na V ) channels drive the upstroke of the action potential and are comprised of a pore-forming α-subunit and regulatory β-subunits. The β-subunits modulate the gating, trafficking, and pharmacology of the α-subunit. These functions are routinely assessed by ectopic expression in heterologous cells. However, currently available expression systems may not capture the full range of these effect...

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Literature Corpus work: 008f4eeb-388c-524d-9aed-16eef7c116ac
DOI: 10.1101/2023.07.08.548226

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