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Article

3D microfluidic tumor models for biomimetic engineering of glioma niche and detection of cell morphology, migration and phenotype change.

Talanta - 1 Nov 2021

Lin Ling, He Ziyi, Jie Mingsha, Lin Jin-Ming, Zhang Jie

Abstract excerpt

In this work, an integrated 3-dimensional microfluidic device was developed for simulation of the immune microenvironment of glioma niche through the co-culture of three kinds of related cells. Glioma cells, endothelial cells and macrophages were co-cultured together in the microfluidic device, spatially separated by the design of a coffer structure and the use of hydrogel. This platform enabled separate...

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Identifiers

PMID: 34364499
DOI: 10.1016/j.talanta.2021.122702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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