Article

Synthetic lethal targeting of <i>TET2</i> -mutant hematopoietic stem and progenitor cells by XPO1 inhibitors

2022-10-13

Abstract excerpt

TET2 inactivating mutations serve as initiating genetic lesions in the transformation of hematopoietic stem and progenitor cells (HSPCs). In this study, we analyzed known drugs in zebrafish embryos for their abilities to selectively kill tet2 -mutant HSPCs in vivo , and we found that the exportin 1 (XPO1) inhibitors, selinexor and eltanexor, selectively kill tet2 -mutant HSPCs. In serial replating colony assays...

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Literature Corpus work: 8559257a-952d-5cf9-b454-f9bfc6dbb37b
DOI: 10.1101/2022.10.12.511957

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