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Article

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.

Blood - 15 Apr 2008

Dayyani Farshid, Wang Jianfeng, Yeh Jing-Ruey J, Ahn Eun-Young, Tobey Erica, Zhang Dong-Er, Bernstein Irwin D, Peterson Randall T, Sweetser David A

Abstract excerpt

Deletions on chromosome 9q are seen in a subset of acute myeloid leukemia (AML) cases and are specifically associated with t(8;21) AML. We previously defined the commonly deleted region in del(9q) AML and characterized the genes in this interval. To determine the critical lost gene(s) that might cooperate with the AML1-ETO fusion gene produced by t(8;21), we developed a set of shRNAs directed against each gene in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18258796
DOI: 10.1182/blood-2007-07-103291
PMCID: PMC2288729

Genes

TLE1
TLE4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.PMID 18258796Read ↗

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.Semantic proximity Read ↗

Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia.Semantic proximity Read ↗

Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.Semantic proximity Read ↗

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Semantic proximity Read ↗

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.Semantic proximity Read ↗

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES proteinSemantic proximity Read ↗

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathSemantic proximity Read ↗

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.Semantic proximity Read ↗

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLsSemantic proximity Read ↗

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cellsSemantic proximity Read ↗

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor CellsSemantic proximity Read ↗

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model.Semantic proximity Read ↗

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