Article

Tet2-mediated DNA demethylation regulates the proliferation and apoptosis of human leukemia K562 cells

2022-05-24

Abstract excerpt

<title>Abstract</title> <p>Tet2 is one member of TET protein family which is responsible for active DNA demethylation, and mutations of Tet2 frequently lead to hematological malignancies. However, the relationship between Tet2-mediated demethylation and the occurrence of hematological malignancies is unclear. Human leukemia K562 cell line was an immortalized leukemia line that of served as an in vitro model of er...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d2bf9e9-bde1-5c04-b983-e4203e676bf7
DOI: 10.21203/rs.3.rs-1668398/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tet2-mediated DNA demethylation regulates the proliferation and apoptosis of human leukemia K562 cellsDOI 10.21203/rs.3.rs-1668398/v1Read

[TET2 as a gatekeeper for hematologic malignancies].Semantic proximity Read

Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies.Semantic proximity Read

[Mutation of tet2 gene and malignant blood disease].Semantic proximity Read

TET2 as an epigenetic master regulator for normal and malignant hematopoiesis.Semantic proximity Read

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic MalignanciesSemantic proximity Read

The TET2 interactors and their links to hematological malignancies.Semantic proximity Read

TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights.Semantic proximity Read

The prognostic impact of tet oncogene family member 2 mutations in patients with acute myeloid leukemia: a systematic-review and meta-analysisSemantic proximity Read

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis.Semantic proximity Read

TET2 mutational status affects myelodysplastic syndrome evolution to chronic myelomonocytic leukemiaSemantic proximity Read

Down-regulation of TET2 in CD3⁺ and CD34⁺ cells of myelodysplastic syndromes and enhances CD34⁺ cells proliferation.Semantic proximity Read

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.Semantic proximity Read