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Article

Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation.

PloS one - 1 Jan 2014

Zhang Beibei, Shimada Yasuhito, Kuroyanagi Junya, Umemoto Noriko, Nishimura Yuhei, Tanaka Toshio

Abstract excerpt

Zebrafish-based chemical screening has recently emerged as a rapid and efficient method to identify important compounds that modulate specific biological processes and to test the therapeutic efficacy in disease models, including cancer. In leukemia, the ablation of leukemia stem cells (LSCs) is necessary to permanently eradicate the leukemia cell population. However, because of the very small number of LSCs in...

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Source

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Identifiers

PMID: 24454867
DOI: 10.1371/journal.pone.0085439
PMCID: PMC3893211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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