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Article

AML1-ETO reprograms hematopoietic cell fate by downregulating<i>scl</i>expression

21 Dec 2007

Abstract excerpt

AML1-ETO is one of the most common chromosomal translocation products associated with acute myelogenous leukemia (AML). Patients carrying the AML1-ETO fusion gene exhibit an accumulation of granulocyte precursors in the bone marrow and the blood. Here, we describe a transgenic zebrafish line that enables inducible expression of the human AML1-ETO oncogene. Induced AML1-ETO expression in embryonic zebrafish causes...

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PMID: 18156164
DOI: 10.1242/dev.008904

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