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Article

A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels.

The Journal of biological chemistry - 15 Nov 2002

Tran Neil, Proenza Catherine, Macri Vincenzo, Petigara Fiona, Sloan Erin, Samler Shannon, Accili Eric A

Abstract excerpt

Pacemaker channels are formed by co-assembly of hyperpolarization-activated cyclic nucleotide-gated (HCN) subunits. Previously, we suggested that the NH(2) termini of the mouse HCN2 isoform were important for subunit co-assembly and functional channel expression. Using an alignment strategy together with yeast two-hybrid assays, patch clamp electrophysiology, and confocal imaging, we have now identified a domain...

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Source

Identifiers

PMID: 12193608
DOI: 10.1074/jbc.M208477200

Genes

HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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