Article
Protein-Protein Interactions in the Cyanobacterial Circadian Clock: Structure of KaiA Dimer in Complex with C-Terminal KaiC Peptides at 2.8 Å Resolution.
Biochemistry - 4 Aug 2015
Pattanayek Rekha, Egli Martin
Abstract excerpt
In the cyanobacterial circadian clock, the KaiA, -B, and -C proteins with ATP constitute a post-translational oscillator. KaiA stimulates the KaiC autokinase, and KaiB antagonizes KaiA action. KaiA contacts the intrinsically disordered C-terminal regions of KaiC hexamer to promote phosphorylation across subunit interfaces. The crystal structure of KaiA dimer from Synechococcus elongatus with two KaiC C-terminal...
Topics
- Bacterial Proteins
- Circadian Rhythm Signaling Peptides and Proteins
- Crystallography, X-Ray
- Models, Molecular
- Mutation
- Peptides
- Protein Multimerization
- Protein Structure, Quaternary
- Protein Structure, Secondary
- Synechococcus