Article

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes

2024-01-22

Abstract excerpt

In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternative polyadenylation, impacting expression of disease-relevant genes (e.g., ELP1, NEFL, and TMEM106B ) and providing...

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Literature Corpus work: aaa596e8-e5aa-5f3b-8f5d-29200507d3aa
DOI: 10.1101/2024.01.22.575730

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