Article

On-Pathway Oligomer of Human Islet Amyloid Polypeptide Induced and Stabilized by Mechanical Rotation During MAS NMR

2023-07-08

Abstract excerpt

Intermediates along the fibrillation pathway are generally considered to be the toxic species responsible for the pathologies of amyloid diseases. However, structural studies of these species have been hampered by heterogeneity and poor stability in standard aqueous conditions. Here, we report a novel methodology for producing stable, on-pathway oligomers of the human Type-2 Diabetes-associated islet amyloid polyp...

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Literature Corpus work: 851e3c70-46a4-53ba-88d4-15668c96a7df
DOI: 10.1101/2023.07.06.547982

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